Our research unit is formed by a multidisciplinary team composed of biologists, medical oncologists and pathologists with the common objective of understanding the molecular alterations involved in cancer to help in patients´ diagnosis and prognosis.
We have currently several projects on going aimed to find new biomarkers and molecular targets that can be used towards a precision medicine, opening new avenues in the therapeutic options, using tissue and liquid biopsies. We believe that our work is predestined to have a clear clinical application that could change cancer diagnosis and would help oncologists for personalized treatments.
Martinez VG, …, Martínez-Fernández M and Paramio JM. Epigenetics of Bladder
Cancer: Where Biomarkers and Therapeutic Targets Meet. Front. Genet. 10:1125 (2019).
Segovia, San José-Enériz , Munera-Maravilla*, Martínez-Fernández M et al
Inhibition of a G9a/DNMT network triggers immune-mediated bladder cancer regression. Nature Medicine, 25: 1073–1081 (2019).
Dueñas, …, Mónica Martínez-Fernández.
Gene Expression Analyses in Non Muscle Invasive Bladder Cancer Reveals a Role for Alternative Splicing and Tp53 Status. Scientific Reports, 9: 10362 (2019).
Projects (PI: Mónica Martínez-Fernández)