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GENOMES & DISEASE

'We investigate the patterns and mechanisms of genomic variation in disease'

Iria Gómez Touriño, PhD | Associate Professor | Principal Investigator of the "Immunity and Small Molecules Lab"

iria.gomez.tourino@usc.es | LinkedIn | ORCID 0000-0001-6594-6110 | Twitter

Dr. Iria Gomez-Tourino (Spain, 1982) is Associate Professor of Immunology at the USC. She has been awarded several fellowships, amounting for more than 540 000€, including two prestigious Marie Sklodowska-Curie Individual fellowships (King’s College London, UK, 2013-2015, and USC, Spain, 2018-2020). Dr. Gomez holds the I3 certificate on research quality, and published 14 articles in the last 10 years in the Immunology field, 86% in Q1 journals and, of those, 67% in D1, including first authorships in Nature Communications and FASEB Journal. She has recently been awarded a research project by the Spanish Ministry of Science and Innovation-Carlos III Institute of Health (2021 call). She is also very active in outreach and science communication activities.

Iria Gomez-Tourino’s main research interests are (i) the identification and characterization of novel anti-inflammatory small molecules for the treatment of autoimmune and inflammation-driven diseases, and (ii) the study of mechanisms of autoimmunity and their relationship with environmental factors.

“The immune system possesses the incredible ability of dealing with foreign threats and endogenous tumour cells while not harming self. The ability of our defences to keep this subtle equilibrium under control fully amazes me. As such, I aim to contribute to the understanding of the functioning of the immune system in health and disease, particularly when tolerance to self is breached. During the last years, I am also becoming interested in how our current way of life, where toxins, food additives and drugs are more ubiquitous than ever before, could be involved in the worrying global increase of the incidence of immune-related diseases”.



Timeline



Grants


  1. Principal Investigator of the project “Characterization of novel small molecules with anti-inflammatory capabilities for the treatment of rheumatoid arthritis (Halt!Inflamm)”, funded by the Spanish Ministry of Science and Innovation-Carlos III Institute of Health (Jan 2022-Dec 2024).
  2. Marie Skłodowska-Curie individual fellowship, at the Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), University of Santiago de Compostela, Spain (Jul 2018-Jun 2020).
  3. Travel grants to attend the 14th and 15th Immunology of Diabetes Society congresses (Munich, Germany, Apr 2015. San Francisco, USA. Jan 2017)
  4. Marie Curie Individual Fellowship, at the Dpt. of Immunobiology, King’s College London (UK) (Jun 2013 –May 2015).
  5. Grant to attend the 64th Nobel Laureate Meeting (Physiology or Medicine) (Jul, 2014).
  6. Barrié de la Maza postdoctoral fellowship, awarded for 2 years for the Dpt. of Immunobiology, King’s College London (Oct 2012-May 2013).
  7. Researcher travel bursary to attend the Researcher Careers and Mobility Conference organized by the Irish Presidency of the EU to contribute to the development of the European Research Area (May 2013).
  8. Ramón Areces postdoctoral fellowship awarded for 1 year for the Dpt. of Immunobiology, King’s College London. Kindly withdrawn in favour of the Barrié de la Maza fellowship (Jun 2012).
  9. Travel grant from the Spanish Society of Immunology to attend the European Congress of Immunology (Glasgow, Sep 2012).
  10. María Barbeito Predoctoral fellowship from the Galician Government (December 2007-Jun 2010).
  11. Fellowship from the Galician Government (Spain) for a 6-month predoctoral stay (6 months) (Oct 2008-Mar 2009).
  12. Research fellowship for the 2nd year of masters’; Galician Government (Spain) (Oct 2006-Sep 2007).
  13. Research fellowship for the 1st year of masters’; Galician Government (Spain) (Oct 2005-Sept 2006)


Selected publications (last 10 years)


  1. Sefina Arif; Iria Gómez-Touriño ; et al. GAD-Alum immunotherapy in type 1 diabetes expands bi-functional, Th1/Th2, autoreactive CD4 T cells. Diabetologia 2020. Jun;63(6):1186-1198.
  2. Calviño-Sampedro C, Gomez-Tourino I , et al. (* Both authors contributed equally to this work). Naturally presented HLA class I-restricted epitopes from the neurotrophic factor S100-β are targets of the autoimmune response in type 1 diabetes. FASEB J. 2019 May;33(5):6390-6401.
  3. Gomez-Tourino I, et al. Shorter T cell receptor beta-chain CDR3 regions in type 1 diabetes result in enhanced repertoire diversity and sharing. Nat Commun 2017 Nov 27;8(1):1792.
  4. Brian D. Stadinski, Karthik Shekhar, Iria Gómez-Touriño, et al. Hydrophobic CDR3 residues promote the development of self-reactive T cells. Nat Immunol. 2016 Aug;17(8):946-55.
  5. A. Das, K. Rouault-Pierre, I. Gomez-Tourino, et al. Adaptive from Innate: Human IFN-γ+CD4+ T Cells Can Arise Directly from CXCL8-Producing Recent Thymic Emigrants in Babies and Adults. J Immunol. 2017 Sep 1;199(5):1696-1705.
  6. Cristina Calviño-Sampedro, Iria Gómez-Tourino, et al. Apportioning blame: autoreactive CD4+ and CD8+ T cells in Type 1 Diabetes. Arch Immunol Ther Exp 2017 Jan 12; 65(4):275-284.
  7. Gomez-Tourino I, et al. T cells in type 1 diabetes: Instructors, regulators and effectors: A comprehensive review. J Autoimmun. 2016 Jan;66:7-16.
  8. Menno van Lummel et al (contains Iria Gómez-Touriño). Discovery of an exclusive islet-peptidome presented by the highest-risk HLA-DQ8trans molecule. Diabetes. 2016 Mar;65(3):732-41.
  9. Iria Gómez-Touriño, et al. Characterization of the autoimmune response against the nerve tissue S100β in patients with type 1 diabetes. Clinical Exp Immunol. 2015 May;180(2):207-17.
  10. Gomez-Tourino, I. "Q&A: Francoise Barre-Sinoussi. HIV adversary". Nature. 2014 Oct 16;514(7522):S8-9.
  11. Menno van Lummel et al (contains Iria Gómez-Touriño). Post-translational modification of HLA-DQ binding islet-autoantigens in type 1 diabetes. Diabetes. 2014 63(1):237-47.
  12. Gómez-Touriño I, et al. Nucleofection of whole murine retinas. Cytotechnology 2013 Aug;65(4):523-32.
  13. Gómez-Touriño I, et al. Galectin-1 synthesis in type 1 diabetes by different immune cell types: reduced synthesis by monocytes and Th1 cells. Cell Immunol. 2011; 271(2):319-28.
  14. Gómez-Touriño I, et al. Autoantibodies to glial fibrillary acid protein and S100beta in diabetic patients. Diabet Med. Feb 2010; 27(2):246-8.

    Patents