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GENOMES & DISEASE

'We investigate the patterns and mechanisms of genomic variation in disease'

Beatriz García Pinel, PhD in Biomedicine. Postdoc Researcher

beagarnel@gmail.com

Currently starting my postdoctoral training at the Immunity and Small Molecules lab. I recently obtained my Ph.D. in Biomedicine, focused on the use of nanoparticles to improve delivery and reduce side effects of first-line treatments used in colorectal cancer.

Education

Selected publications (last 5 years)

  1. García-Pinel, B.; Porras-Alcalá, C.; Ortega-Rodríguez, A.; Sarabia, F.; Prados, J.; Melguizo, C.; López-Romero, J.M. Lipid-Based Nanoparticles: Application and Recent Advances in Cancer Treatment. Nanomater. Basel Switz. 2019, 9, doi:10.3390/nano9040638.

  2. Jabalera, Y.; Garcia-Pinel, B.; Ortiz, R.; Iglesias, G.; Cabeza, L.; Prados, J.; Jimenez-Lopez, C.; Melguizo, C. Oxaliplatin-Biomimetic Magnetic Nanoparticle Assemblies for Colon Cancer-Targeted Chemotherapy: An In Vitro Study. Pharmaceutics 2019, 11, E395, doi:10.3390/pharmaceutics11080395.

  3. Ortiz, R.; Cabeza, L.; Perazzoli, G.; Jimenez-Lopez, J.; García-Pinel, B.; Melguizo, C.; Prados, J. Nanoformulations for Glioblastoma Multiforme: A New Hope for Treatment. Future Med. Chem. 2019, 11, 2459–2480, doi:10.4155/fmc-2018-0521.

  4. Cabeza-Montilla, Laura; Jiménez -Luna, Cristina; García-Pinel, Beatriz; Mesas, Cristina; Quiñonero F; Perazzoli, Gloria. Verapamil modulates p-glycoprotein expression in resistant colon cancer cells. Actas de Investigación Oncológica. 2020, 3, ISSN 2695-3781.

  5. Garcia-Pinel, B.; Ortega-Rodríguez, A.; Porras-Alcalá, C.; Cabeza, L.; Contreras-Cáceres, R.; Ortiz, R.; Díaz, A.; Moscoso, A.; Sarabia, F.; Prados, J.; et al. Magnetically Active PNIPAM Nanosystems as Temperature-Sensitive Biocompatible Structures for Controlled Drug Delivery. Artif. Cells Nanomedicine Biotechnol. 2020, 48, 1022–1035, doi:10.1080/21691401.2020.1773488.

  6. Garcia-Pinel, B.; Jabalera, Y.; Ortiz, R.; Cabeza, L.; Jimenez-Lopez, C.; Melguizo, C.; Prados, J. Biomimetic Magnetoliposomes as Oxaliplatin Nanocarriers: In Vitro Study for Potential Application in Colon Cancer. Pharmaceutics 2020, 12, doi:10.3390/pharmaceutics12060589.

  7. García-Pinel, B.; Porras-Alcalá, C.; Cabeza, L.; Ortiz, R.; Prados, J.; Melguizo, C.; Cheng-Sánchez, I.; López-Romero, J.M.; Sarabia, F. Bengamide Analogues Show A Potent Antitumor Activity against Colon Cancer Cells: A Preliminary Study. Mar. Drugs 2020, 18, 240, doi:10.3390/md18050240.

  8. Rama, A.R.; Perazzoli, G.; Cabeza, L.; Mesas, C.; Quiñonero, F.; García-Pinel, B.; Vélez, C. Novel MicroRNA Sponges to Specifically Modulate Gene Expression in Colon Cancer Cells. Nucleic Acid Ther. 2020, 30, 325–334, doi:10.1089/nat.2020.0861.

  9. Ortíz, R.; Quiñonero, F.; García-Pinel, B.; Fuel, M.; Mesas, C.; Cabeza, L.; Melguizo, C.; Prados, J. Nanomedicine to Overcome Multidrug Resistance Mechanisms in Colon and Pancreatic Cancer: Recent Progress. Cancers 2021, 13, 2058, doi:10.3390/cancers13092058.

  10. Alvear-Jiménez, A., Zabala Gutierrez, I., Shen, Y., Villaverde, G., Lozano-Chamizo, L., Guardia, P., Tinoco, M., Garcia-Pinel, B., Prados, J., Melguizo, C., López-Romero, M., Jaque, D., Filice, M., & Contreras-Cáceres, R. (2022). Electrospraying as a Technique for the Controlled Synthesis of Biocompatible PLGA@Ag2S and PLGA@Ag2S@SPION Nanocarriers with Drug Release Capability. Pharmaceutics, 2022 14(1), 214. https://doi.org/10.3390/pharmaceutics14010214