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GENOMES & DISEASE

'We investigate the patterns and mechanisms of genomic variation in disease'

Translational Molecular Oncology

This research line includes a multidisciplinary team composed of biologists, medical oncologists and pathologists with the common objective of understanding the molecular alterations involved in cancer to help both in patients´ diagnosis and prognosis. Our main aim is to find new biomarkers and molecular targets that can be used towards a precision medicine, opening new avenues in the therapeutic options, using tissue and liquid biopsies.

Currently, we have a project focused in the possible role as oncogenes of a subset of active L1 retrotransposon elements in lung, colorectal, and head and neck tumours. We have developed a novel targeted sequencing-based method for the detection of high-activity rates of individual L1 elements in cancer samples. This promising tool allows studying the molecular consequences of L1 activation in tumor initiation, progression and treatment response. We believe that its clinical application could change cancer diagnosis and would help oncologists for personalized treatments.

Team

Communications

Links of interest

https://proxectooctopus.org/

ESTUDIO DEL IMPACTO FUNCIONAL DE LA TRANSDUCCIÓN DE SECUENCIAS REGULADORAS MEDIADA POR RETROTRANSPOSONES ALTAMENTE MUTAGÉNICOS EN TUMORES HUMANOS